All rights reserved. Pregnant women should not use celery seed because it may lead to uterine bleeding and muscle contractions in the uterus, which could cause miscarriage. Gral N, Beani JC, Bonnot D, et al. The study showed reduced inflammation in the mice (x). Crispy, crunchy celery has a number of benefits that may surprise you. Rich in Important Nutrients. A new French multicenter survey]. Celery (Apium graveolens) contains many beneficial plant compounds, which are found primarily in the seeds of the plant. (2014). Boffa, M. J., Gilmour, E., and Ead, R. D. Celery soup causing severe phototoxicity during PUVA therapy. Zhou Y, Taylor B, Smith TJ, Liu ZP, Clench M, Davies NW, Rainsford KD. A novel compound from celery seed with a bactericidal effect against Helicobacter pylori. Reducing uric acid levels with luteolin might reduce the frequency of gout flare-ups. Therefore, researchers suggest that extract from the seeds may have potential as a natural food preservative (27). These properties may be especially beneficial in reducing inflammation in conditions such as gout. View abstract. Reductions in plasma glucose levels were reported, but not in plasma insulin levels.Yusni 2018, A protective effect of celery leaves and seeds on gastric ulceration has been demonstrated in studies of rats.Al-Howiriny 2010, Baananou 2013, Hydroalcoholic extracts of whole A. graveolens plant may have a role in the management of gout, based on reduced serum uric acid levels in a study of rodents with induced hyperuricemia. A case of Apium graveolens (Celery) induced hyperthyroidism. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. Blood-thinning medications (anticoagulants and antiplatelets): Celery seed contains chemicals that may thin the blood. Celery and Celery Seed Extract Are Powerful, Proven Healers Cutis 2002;70(1):29-30. So I tried it. Iron is a mineral essential for producing red blood cells. During ancient times, Indian Ayurvedic medicine used celery seed to treat colds, flu, water retention, poor digestion, different types of arthritis, and certain diseases of the liver and spleen. 2008;56(11):3997-4003. Luteolin may reduce uric acid levels and reduce inflammatory nitric oxide production. High blood pressure is the largest contributor for this disease. Fresh celery contains important nutrients but celery seed extract in supplements may cause side effects. WebMany subjects noticed the celery seed extract produced a diuretic effect, but no changes were noted in their sodium and potassium balances. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Celery supplements are available as celery seed extract, fresh or dried seeds, tablets and as capsules filled with celery seed oil. Am J Clin Nutr. Vitamin C enhances the absorption of non-heme iron in plant foods like celery seeds. Eastern medicine has used celery seeds for thousands of years to treat ailments like bronchitis, skin disorders, and the flu (1). J Pharm Pharmacol. However, various research studies may give us a starting place for beneficial dosages in humans. In the UK Women's Cohort Study conducted in 13,958 women (with approximately 4 years of follow-up), consumption of an additional portion of celery (among other plants) was inversely associated with sleep duration.Noorwali 2018, Limited studies in rodents suggest celery seed extract possesses hypoglycemic effects.Yusni 2018, Very limited clinical data exist regarding the effects of celery leaf or seed extract in diabetes. Celery seeds are a great source of iron for both men and women. If you experience any of the following symptoms, get immediate medical attention: Before taking a supplement containing celery seed extract, ask your doctor if you are on any medication that may interact with the herb. Springhouse, PA: Springhouse Corp., 1999. If you have gout, try turmeric as a home remedy. A review of the antioxidant activity of celery (. In one animal study, researchers investigated the impact of luteolin on nitric oxide produced from uric acid. The coumarin glucoside apiumoside has also been identified. Wang, L., Sterling, B., and Don, P. Berloque dermatitis induced by "Florida water". Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Celery seed has been used as medicine for thousands of years in the Eastern world. During June and July, small white flowers bloom and later bear the smooth gray seeds. Hypolipidemic and antioxidant activity of mountian celery seed essential oils. Inhibition of platelet aggregation by apigenin from Apium graveolens. Eating foods rich in vitamin C like berries, citrus fruits, or bell peppers in meals with the seeds can help optimize non-heme iron absorption (15, 18). In fact, they contain a variety of antioxidants and anti-inflammatory compounds and serve as a common treatment for gout, arthritis, menstrual cramps, inflammation and high blood pressure (x). celery seed extract, fresh or dried seeds, tablets and as capsules filled with celery seed oil. In fact, each pill has a higher dosage of celery seed extract plus the addition of the tart cherry, and at a lower price. Based on the positive results in this small pilot study, a larger 70-patient study was conducted. Rueff, F., Eberlein-Konig, B., and Przybilla, B. People with low blood sugar, acute kidney inflammation, or an allergy to celery seeds or birch pollen should also avoid taking celery seed (34). Lastly, celery seeds also contain magnesium and phosphorus. WebMy recommendation is to either consume eight ribs of celery per day or take a celery seed extract standardized to contain 85 percent 3nB and other celery phthalides at a dosage Its most active chemical, curcumin, has potent anti-inflammatory and antioxidant properties. 2018;39(2):154-160. These benefits may also be found in the beta-selinene in celery seed, but this study didnt test celery specifically. Saudi Med J. Be sure to wear sunblock and protective clothing when spending time in the sun. DOI: Chandra M, et al. J Ethnopharmacol 2021;264:113400. Bleeding may occur. Moreover, these compounds fight against certain cancers including intestinal cancer, breast cancer and leukemia by preventing mutated malignant cells from multiplying (x). Celery supplements are available as celery seed extract, fresh or dried seeds, tablets and as capsules filled with celery seed oil. Although celery seed and extract is used to treat a number of health conditions, few human studies support this, and you may experience side effects with its use. in blood pressure. If you buy through links on this page, we may earn a small commission Heres our process. 1995;49:119-126. BuPh, or 3-n-butylphthalide, is a compound present in celery that improves heart health due to its lipid-lowering capabilities. Tuetun, B., Choochote, W., Pongpaibul, Y., Junkum, A., Kanjanapothi, D., Chaithong, U., Jitpakdi, A., Riyong, D., Wannasan, A., and Pitasawat, B. Rouhi-Boroujeni H, Hosseini M, Gharipour M, Rouhi-Boroujeni H. Is herbal therapy safe in obesity? Abstract. WebThe author also recommends celery seed tinctures to treat sharp headaches over the eye and temple area that last all night, and for throbbing aches in the temple. Theyre small, light-brown, and have an earthy scent. Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil. Adv Orthop. View abstract. Here are a few more ways to add celery seeds to your diet: Interestingly, some people use ground celery seed to make tea. Most people can safely use celery seeds in cooking. 2012;66:132-4. Celery seeds are a great source of magnesium. Here are five reasons you should consider adding celery to your diet. People with active kidney inflammation should not take celery seed. Banerjee S, Sharma R, Kale RK, Rao AR. We include products we think are useful for our readers. Celery is a popular vegetable, but theres more to this plant than the stalk alone. You can easily add celery seeds to your diet by adding them to soups, side dishes, and even hot tea. Plus, theyre available in supplemental form.You can find both the spice and celery seed supplements locally or online. Taking celery seed along with levothyroxine might reduce the effects of levothyroxine. Lithium: Celery seed may alter how this medication is excreted in the body. 2010;48(1):93-98. If you have low blood pressure, you should use caution when considering celery seed extract as a supplement. The essential oil produces sedative effects. View abstract. 2008;63(2):243-4. Prospective, multicenter evaluation of a polyherbal supplement alongside standard-of-care treatment for mild knee osteoarthritis. J Pharm.Biomed.Anal. Celery products, such as seeds and juice, are readily available at grocery stores and health food shops. View abstract. (2018). Coronary heart disease is the leading cause of death in many countries. Theyre particularly rich in various minerals, such as calcium, iron, and manganese. Stalking hypertension. View abstract. Monitor therapy.Hui 2009, Nonsteroidal anti-inflammatory agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of nonsteroidal anti-inflammatory agents. ARYA Atheroscler 2016;12(5):248-9. Hoerler, S. and Ukiwe, J. Laryngeal edema from celery allergic reaction. Other constituent compounds have been identified. (2017). Combined with the high fiber content, celery seed extract can help maintain regularity and reduce bloating (x). Inhibition of cell adhesion, antiangiogenic properties, proapoptosis, and other effects have been demonstrated in studies using human cancer cell lines.Iyer 2019, Kasiri 2018, Kowalczyk 2017, Sung 2016 In vitro and rodent studies suggest essential oil from celery may also possess cytotoxic and antimutagenic properties.Christensen 2006, Hashim 1994, Lim 2013, Zheng 1993, Celery extract has demonstrated vasorelaxant effects on isolated rat aortic rings.Jorge 2013 Celery seed extract exerted hypotensive effects in hypertensive, but not normotensive, rats, possibly due to the n-butylphthalide content.Moghadam 2013, Tang 2017 Limited studies in rodents report improved lipid profiles with celery seed extracts.Abd El-Mageed 2011, Iyer 2011, Iyer 2019, Rouhi-Boroujeni 2015 Additional effects in cardiovascular disease include decreased secretion of proinflammatory cytokines.Tang 2017, Limited clinical studies have been conducted to evaluate the effects of the extracted compound butylphthalide in strokeWang 2018; one study demonstrated superiority of 90-day treatment with dl-3-n-butylphthalide (a synthetic variation of l-3-n-butylphthalide, an extract from seeds of A. graveolens) over aspirin in patients with acute ischemic stroke.Cui 2013 The synthetic version of the compound is clinically approved as an anti-ischemic agent in China.Abdoulaye 2016, In older studies, 3-n-butylphthalide showed sedative and anticonvulsant effects in rodents.Khan 2009 In induced Parkinson disease models in mice, extracts from whole A. graveolens plant improved behavioral performance, oxidative stress parameters, and monoamine oxidase A and B activity.Chonpathompikunlert 2018, Huang 2010 Other studies in rodents report improvements in cognition and depression, and modulation of endogenous antioxidant and neurotransmitter systems.Boonruamkae 2017 Reviews exist regarding neuroprotective effects of the flavone luteolin, which is found in several plant products, including celery.Nabavi 2015, Clinical studies are lacking. A lower bone mineral density is associated with an increased risk of fractures, especially in older adults. But there are some gout remedies you can try at home to prevent or treat future, While gout usually first affects joints in your feet, such as your big toe, its also possible to develop gout in your other joints, including your. (2019). Sultana S, Ahmed S, Jahangir T, Sharma S. Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development. 1995;61:18-21. Iron deficiency is the most common micronutrient deficiency worldwide, but eating more iron-rich foods has been shown to lower your risk of deficiency and subsequent anemia (16, 17). Choochote W. et al., Potential of crude seed extract of celery, Apium graveolens L., against the mosquito Aedes aegypti (L.) (Diptera: Culicidae). DeChamp, C., Michel, J., Deviller, P., and Perrin, L. F. [Anaphylactic shock to celery and sensitization to ragweed and mugwort. The symptoms, likely due to a CYP2D6-dependent interaction, resolved upon cessation of the celery root extract.Khalid 2016, In a study in rats given an extract of fresh celery, increased plasma captopril levels were reported.Siska 2018, Antithrombotic effects have been described for celery seed extracts.Cui 2013 Potentiation of monoamine oxidase inhibitors is possible.Jger 2013, Agents with antiplatelet properties: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of agents with antiplatelet properties. However, celery was just one part of their diet. The dose depends on what you are taking it for and which form Celeriac, or celery root, is a relatively unknown root vegetable packed with nutrients. Tsi D, Das NP, Tan BK. 2023 Healthline Media LLC. The Department of Pharmacology at the University of Singapore put mice on a high-fat diet for eight weeks. In fact, celery can satisfy hunger since it fills the stomach and is not as calorically dense as other foods. View abstract. Christensen, L. P. and Brandt, K. Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. Polysaccharides and antioxidants like phenolic acids and flavanols found in celery seeds fight oxidative stress and free radical damage. Atta AH, Alkofahi A. Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. Celery seed oil is obtained by steam distillation of the seed. View abstract. In many countries, celery is harvested primarily for its seeds due to the medicinal properties they contain. Tuetun, B., Choochote, W., Kanjanapothi, D., Rattanachanpichai, E., Chaithong, U., Chaiwong, P., Jitpakdi, A., Tippawangkosol, P., Riyong, D., and Pitasawat, B. Repellent properties of celery, Apium graveolens L., compared with commercial repellents, against mosquitoes under laboratory and field conditions. However, more research in humans is needed. View abstract. J Vector Ecol. Consider therapy modification.Mousa 2010, Spolarilch 2007, Stanger 2012, Ulbricht 2008, Thrombolytic agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of thrombolytic agents. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. All rights reserved. Hessami K, Rahnavard T, Hosseinkhani A, et al. In one trial, dl-3-n-butylphthalide 400 mg orally daily (given as one 200 mg capsule twice daily) as part of a 90-day treatment regimen was used to improve outcomes in patients with acute ischemic stroke. This study suggests that luteolin might provide some protection from uric acid-induced inflammation in gout. Avoid use. View abstract. Though celery seeds are most commonly used as a cooking spice, theyre also available in other supplemental forms: These forms offer a concentrated dose of celery seed. Celery is blanched to generate the edible white stem during cultivation by burying the stem. Read more: The 27 Safest Sunscreens and 3 to Avoid. (2016). Supports circulation to the heart and brain*. Celery seeds contain several substances, including: Scientists have not studied celery seeds in children, so it is not recommended for use in children under 18. Bull.Acad.Natl.Med 1995;179(1):161-184. In addition, potential celery seed benefits include the treatment of ailments such as edema, gout, flatulence, chronic pneumonia and obesity. Celery is known to be dangerous for allergic individuals. In about 450 BC, the Greeks used celery to make a type of wine called selinites, which was given as an award at early athletic games, much like laurel leaves or olive branches. View abstract. Along with a healthy diet, seeds can help reduce blood sugar, cholesterol and blood pressure. Asia Pac J Pharmacol. 2010 Jul;48(7):786-93. Manganese is needed to activate enzymes that produce proteins necessary for the formation of bone tissue and cartilage. A handful of celery seeds will help cleanse your urinary tract and keep it void of any unwanted bacteria. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Allergy. Baek CH, Bae YJ, Cho YS, Moon HB, Kim TB. Web1) celery seed extract (tried this after using celery seed on its own to no success) 2) sunflower lecithin. What Are the Benefits of Celery Seed Tea? There is a cross reactivity with all forms of celery, including celery salt, celery root, celery seed and commercial products that contain celery seed, such as Old Bay seasoning. As a member of the parsley family, it is prominent in American cooking. Conflicting conclusions have been drawn regarding the rate of absorption of apigenin. Effects of aqueous celery (Apium graveolens) extract on lipid parameters of rats fed a high fat diet. 2005;221(1):11-20. All rights reserved. Unsurprisingly, the flavor of celery seed resembles that of a celery stalk. View abstract. Ultraviolet spectrographic studies have indicated the presence of a compound similar or identical to 8-methoxypsoralen. 2009 Aug;61(8):1067-77. View abstract. So it could make the effects of other diuretics stronger and raise the risk of dehydration. 5 Healthy Benefits of Adding Celery to Your Diet, What Is Celeriac? 10 Facts You Need to Know About Food Allergies, Penn State Hershey Medical Center: "Celery Seed", Journal of Drug Discovery and Therapeutics: "Medical Benefits of Apium Graveolens (Celery Herb", Preventive Medicine and Food Science: "Inhibitory Effects of Apium graveolens on Xanthine Oxidase Activity and Serum Uric Acid Levels in Hyperuricemic Mice", Pharmacognosy Review: "An Updated Phytopharmacological Review on Medicinal Plant of Arab Region: Apium Graveolens Linn", Natural Medicine Journal: "A Pilot Study to Evaluate the Antihypertensive Effect of a Celery Extract in Mild to Moderate Hypertensive Patients", American Academy of Allergy, Asthma, Immunology: "Allergy to Celery", University of Nebraska - Lincoln: Food Allergy Research and Resource Program: "Allergenic Foods and their Allergens, with links to Informall", A swollen throat or the constriction Celery Seed Extract: Benefits, Side Effects & Dosage, celery seed extract for high blood pressure, Ectopic Pregnancy: Characteristics, Causes & Treatment , Cayenne Pepper: Benefits, Side Effects & Dosage. Celery juice might decrease how quickly the liver breaks down and removes aminopyrine. With many different standardizations, the dosages may differ between supplements. The effects of celery leaf (apium graveolens L.) treatment on blood glucose and insulin levels in elderly pre-diabetics. View abstract. 1994;21:263-269. Other reactions that can result from handling the plant or eating large amounts of celery seeds include tiredness, slowed breathing and decreased heartbeat, warns Summit Medical Group. Antiadhesive hydroalcoholic extract from Apium graveolens fruits prevents bladder and kidney infection against uropathogenic E. coli. A study conducted on male rats found that celery extracts enhance sexual performance ( 23 ). Ballmer-Weber, B. K., Hoffmann, A., Wuthrich, B., Luttkopf, D., Pompei, C., Wangorsch, A., Kastner, M., and Vieths, S. Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. In short, celery is a plant based alternative to preserving and curing organic meat and other products. Bleeding may occur. Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin. We comply with the HONcode standard for trustworthy health information. Celery Seed Oleoresin is a natural extract derived from the seeds of the celery plant. 2023 Healthline Media LLC. Incorporate them into your barbeque dishes like coleslaw or potato salad. See additional information. Concerns for Pregnant Women Pregnant women should avoid large doses of celery and celery seed as it can induce bleeding and uterine contractions. 1991;127(6):912-913. 2004;29(2):340-6. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Herbal infusions used for induced abortion. View abstract. Ann.Allergy 1985;54(2):166. To illustrate, celery extract protects the lining of the stomach, esophagus and duodenum and can prevent peptic ulcers. Int J Prev Med 2019;10:55. doi: 10.4103/ijpvm.IJPVM_209_17. View abstract. celery seed extract in 1,000 mg increments once to three times daily, or as Hirschfeld G, Weber L, Renkl A, Scharffetter-Kochanek K, Weiss JM. However, theyre also available as a supplement in extract or capsule form. In one trial, dl-3-n-butylphthalide 400 mg orally daily (given as one 200 mg capsule twice daily) as part of a 90-day treatment regimen was used to improve outcomes in patients with acute ischemic stroke. The most common location of gout pain is the large toe, although it can occur in other joints too. DL-3-n-butylphthalide protects endothelial cells against advanced glycation end product-induced injury by attenuating oxidative stress and inflammation responses. J.Emerg.Med. Celery contains chemo-protective compounds known as polyacetylenes, which have immune-boosting benefits. J AOAC Int 2001;84(4):1135-1143. Part 182 -- Substances Generally Recognized As Safe. It has 3 to 5 segmented leaves and flowers with small white petals. Herbalists recommend celery for treatment of arthritis, nervousness, and hysteria. Treatment of women's sexual dysfunction using Apium graveolens L. Fruit (celery seed): a double-blind, randomized, placebo-controlled clinical trial. The drug industry uses Celery Seed Oleoresin for its anti-inflammatory Postgrad Med. Blood thinners include aspirin, warfarin (Coumadin), and clopidogrel (Plavix). More n Vito research is needed to verify these preliminary findings. Advertisement references Egan, C. L. and Sterling, G. Phytophotodermatitis: a visit to Margaritaville. 1993;19:77-86. Conventional mosquito repellents contain higher concentrations of DEET or picardin. Objective: To evaluate the efficacy of a standardized extract of celery seed, 150 mg/d, supplying 85% 3-n-butylphthalide (3nB) in mild to moderate hypertensive You should avoid taking celery seed extracts and supplements if you are pregnant or trying to conceive. See additional information. There are plenty of celery seed supplements on the market to explore. 2018;127:237-244. Luteolin prevents uric acid-induced pancreatic -cell dysfunction. Including magnesium-rich foods like celery seeds in your diet may reduce your risk of type 2 diabetes. The most notable compounds in celery seed include: These compounds have been researched for their role in inflammation and uric acid production, which is a driving force behind the severity of gout attacks. WebServing Size: 1 capsule 150 mg per serving 60 servings per container capsule size: 1 Product Description Traditionally used to promote joint and GI health Provides antioxidant support Celery seed is not as widely-recognized in modern Western herbal practices, but its use dates back thousands of years in the East. (2003). Healthline Media does not provide medical advice, diagnosis, or treatment. Maintaining healthy blood sugar levels is important for reducing your risk of type 2 diabetes and heart disease (19, 20). Yusni Y, Zufry H, Meutia F, Sucipto KW. Celery seed oil is a supplement containing a high amount of volatile compounds known as phthalides. Scientific Name(s): Apium graveolens L. var dulce (Mill.) Since then, the plant has been widely used as a food and for medicinal purposes. Last medically reviewed on July 23, 2019. Celery has also been prescribed as an antiflatulent, antilactogen, and aphrodisiac.Al-Asmari 2017, Bisset 1994, Garfield 1985, The celery leafstalk is high in minerals, including sodium, potassium, calcium, magnesium, and iron and nitrates; however, it is a relatively poor source of vitamins except for vitamin C.Afourtit 2015, Meng-Yao 2018. Online ahead of print. Celery root might slow blood clotting. Restricting purine-rich animal foods, like salami, while enjoying a balanced diet rich in plant foods, may help improve gout symptoms. One tablespoon (6.5 grams) of celery seeds provides (2): Celery seeds are low in calories, with a tablespoon providing about 25 calories. Some studies suggest that increasing your calcium intake may reduce your risk of fractures (6, 7, 8, 9). Further studies are needed to confirm these results so, to play it safe, monitor your blood pressure if you are taking a celery supplement. Bauer L, Ebner C, Hirschwehr R, et al. View abstract. DOI: Vieira AT, et al. Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family. However, certain individuals should avoid supplemental celery seed due to safety concerns, particularly pregnant women. Heck AM, DeWitt BA, Lukes AL. Dietary fiber and the short‐chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. A study by the Journal of Pharmaceutical Biology in 2010 showed how the alkaloids, tannins and flavonoids in celery improve mucus production, which in turn controls gastric acid. View abstract. Celery seed has traditionally been used as a diuretic for bladder and kidney complaints, as well as for arthritis and rheumatism. It contains allergens that may provoke severe allergic reactions, including anaphylaxis, reports the 2017 Pharmacognosy Review study.